Preimplantation Genetic Diagnosis (PGD) is a procedure for screening for genetic diseases in an embryo prior to transfer to the uterus. PGD can be used to detect embryos with single gene defects. This allows us to screen for diseases like Tay-Sachs, Cystic Fibrosis, Huntington Disease and Sickle Cell Anemia. PGD can also be used to detect embryos that have chromosomal disorders such as Down’s Syndrome.
PGD must be done in conjunction with IVF. After the eggs are retrieved, they are inseminated with the partner’s sperm via ICSI (Intracytoplasmic Sperm Injection) where they take a single sperm and directly inject it into an egg. If the egg becomes fertilized, it should develop into a 6-10 celled embryo by the third day after fertilization. At this point 1-2 of the embryo’s cells (or blastomeres) are biopsied and then the genetic information is analyzed. The laboratory can then tell which embryos are unaffected for the disease
being screened. Only those unaffected embryos are transferred back to the uterus in hopes of a pregnancy.
For more information on PGD, contact CNY Fertility Center, or visit these websites: