An advanced “protocol” for enhanced results. Our oocyte and implantation enhancement protocols factor in dietary guidance, supplementary support, pharmacological driven reproductive immunology, holistic therapies, and surgical interventions. It is designed to improve oocyte (egg) quality and the uterine environment and thus improve embryo quality, implantation, and live birth results.
The Critical 90
The human egg starts its final developmental stage prior to fertilization approximately 90 days before that egg is ovulated. In order to account for the full period of development and in turn the best quality eggs for your treatment cycle, it is important that some of the enhancement measures make up as long of these 90 days as possible.
Fat is where it’s at
Fat is so important for fertility that we often deliver fat to our patients intravenously (intralipids – more on that below) . . . but if you’re eating enough high-quality fats you shouldn’t need intralipids.
Female Fertility Diet
Decades of clinical experience have shown that the food we eat impacts our fertility perhaps more than anything. We recommend that all women (and men) eat a high fat, moderate protein (because excess protein is converted to sugar via gluconeogenesis), and low carbohydrate diet (AKA a ketogenic diet).
The ketogenic diet improves female fertility via two primary mechanisms:
Reduces Inflammation: Inflammation is the number one root cause of infertility. Eating a Standard American Diet (SAD) means a low-fat diet with excessive amounts of carbohydrates, sugars, grains, fruits, fiber, and vegetables. This high carb diet causes chronically elevated blood sugar which causes inflammation-inducing advanced glycation end products and impaired hormone functioning. A high carbohydrate/plant diet also comes with a burdensome load of phytochemicals that a plant makes to thwart the attack of bugs, pests, molds, and funguses (plants can’t move so they engage in chemical warfare). These molecules are antigens (foreign particles) to the human body and elicit an inflammatory response. Additionally, high plant diets contain lots of fiber that ferments in the gut, producing large amounts of heat – and thus inflammation, right on top of the reproductive organs. Removing this heavy burden and providing the body with large doses of anti-inflammatory fats improves the body’s ability to heal and deliver nutrients to important reproductive organs.
Improves hormone functioning: Many critical fertility hormones are made from cholesterol, but because cholesterol is also imperative for brain function and repair (aka survival) it’s almost impossible to maintain a healthy hormone balance if you’re not eating enough.
Food is the foundation of improving male reproductive health, but there are still many key nutrients that improve fertility that can be hard to come by in nature. It’s important to use high-quality third-party lab tested and verified supplements to help reduce inflammation and provide key missing nutrients like Co-Q10/ubiquinol, inositol, Vitamin D and more. Below, you’ll find all our recommended female fertility supplements.
Loaded with goodies like VESISorb Ubiquinol for a 600 mg deliverable dose of CoQ10, inositol, Vitamin D, PQQ, ovarian glandular and more for improved egg quality, ovarian function and treatment outcomes.
An ultra pure, ultra potent fish oil from Norway that shatters all international standards for purity and potency. One serving of this fish oil delivers 6-8x the Omega 3 as your standard over the counter fish oil.
Inositol helps restore ovulation for those who don’t ovulate regularly (like those with PCOS) and has been shown to improve IVF outcomes for those with and without PCOS. The Ovarian Bloom has some inositol, but if you have PCOS its a good idea to take even more.
The Immunoglobulins (antibodies) in the Fertile Guard have been shown to bind to and prevent antigens in the digestive system from making their way into the bloodstream and causing fertility damaging inflammation.
While dietary and lifestyle changes can go a long way, help from pharmacological medications (outside of traditional fertility medications) can be an important part of your fertility treatment, particularly when dealing with unexplained infertility, repetitive IVF implantation failures, and recurrent pregnancy loss.
Essentially IV administered fat. Intralipids have been shown to improve implantation and reduce pregnancy loss by lowering the activity of the natural killer cells in our immune system.
Low Dose Naltrexone
Traditionally developed to block the effects of opioid medication and treat addiction, LDN acts as an immunomodulator and increases the body’s ability to heal itself.Through unknown mechanisms can improve fertility outcomes.
HGH has been found to help women with poor ovarian reserve testing (e.g., increased FSH, low AMH) and is believed to help with oocyte maturation and improved egg quality.
Eradicates bacteria and thus toxic byproducts and inflammation within the reproductive system that can cause failure to implant and miscarriage.
An immunosuppressant originally developed as an anti-rejection medication for organ transplant recipients. Targets the immune system that can be responsible for recognizing and attacking the embryo as an invader.
A synthetic hormone with anti-inflammatory and immuno-suppressive abilities. Used to treat a range of conditions, including allergies, blood disorders, respiratory problems, skin problems along with fertility issues.
Low-dose aspirin (81mg) treatment has been shown to improve ovarian responsiveness, uterine and ovarian blood flow velocity, implantation, and pregnancy rates in patients undergoing fertility treatments.
Lovenox is an anticoagulant that helps prevent blood clotting and is usually started several days before embryo transfer.It can be prescribed in cases of recurrent miscarriage or where there’s a known blood-clotting disorder.
In IVF, HCG is absent in the uterus because the embryos are in a dish, not in the fallopian tube triggering HCG production. Placing HCG into the endometrium improves it’s “readiness” for transfer.
IVIG is made up of human antibodies. It is not clear exactly how IVIG works, but studies suggest that it may reduce the number of natural killer (NK) cells in the body, and/or may absorb or block a woman’s antibodies, which are causing the body to attack the pregnancy.
filgrastim (Neupogen )
Increases white cells thereby suppressing the immune system so it does not attack the embryo. It can be used as an injection or a wash for the uterus.
Viagra works as a vasodilator which allows for improved blood and nutrition delivery. Used as vaginal suppositories to improve blood flow to the uterus for implantation.
Over the counter Antihistamine’s like Claritin, Pepcid, and Benadryl can be used to suppress the immune system.
Metformin is primarily used in those with PCOS to help regulate and lower insulin levels and balance the metabolic system.
There are 4 main stages/protocols used in our reproductive immunology based enhancement protocols. Of course, there are still things you can add on and mix about… but the below should give you a good idea. Protocols one is often used to improve the success of first time IVF cycles, where two, three, and four are typically used after failed IVF cycles, recurrent pregnancy loss, or other known immunological dysfunction.
A minimally invasive diagnostic and corrective procedure to visualize, investigate, and correct (if discovered) the source of abnormal uterine bleeding or suspected cause of infertility and miscarriage.
A procedure whereby white blood cells from the father to be are isolated from the father’s blood and injected into the skin of the prospective mother to introduce the husband’s immune cells to the woman’s immune system in preparation for pregnancy.
An endometrial biopsy that is then analyzed to determine a woman’s endometrial receptivity (aka how likely an embryo is to stick).The test is performed to help prevent implantation failure by identifying a woman’s unique and optimum “window of implantation.”
PRP is a concentrate of platelet-rich plasma protein derived from whole blood, centrifuged to remove red blood cells. Intraovarian to improve egg quality or intrauterine to improve uterine lining and implantation.
Acupuncture has been proven to improve fertility treatment outcomes. Recommended to start 90 days before treatment but particularly important before and after transfer.
Other Factors Affecting Fertility
We recommend abstaining from all high intensity exercise. Go on a nice long walk or start a yoga for fertility program.
Excessive heat or chemical exposure can have an effect on your fertility. Be mindful of your contact with toxic chemicals and extreme heats like saunas.
Scientific studies are controlled against placebos BECAUSE THE POWER OF BELIEF IS INCREDIBLY STRONG. Practicing meditation and prayer can help manage the stress of life, infertility, and help build a positive belief system.