Intralipids, infertility and your immune system

by
3
Sep

CNY Fertility Center, Rochester, NY - Waiting RoomGreetings from the Staff at CNY Fertility Center in Rochester, NY! The start of the Fall Season brings the expansion of our clinical services we now offer to our clients. We are now scheduling patients to receive their Intralipid Therapy with us at our East Avenue location.
Some types of infertility may be caused by a slightly overactive immune system. When this occurs the immune system can attack egg, sperm, embryo and even a developing fetus. This can result in difficulty achieving pregnancy, maintaining the pregnancy, or repeated miscarriages.
Intralipids have been shown to lower the activity of the natural killer cells component of our immune system. The method of administration is an IV infusion of 90 to 120 minutes duration and require that you are not allergic to soy or egg products,  and also do not have a history of high cholesterol or liver disease. This therapy may be something that can benefit you. For more information regarding call us at 585-244-1280 and have a great Fall!

66 replies
  1. Elaina
    Elaina says:

    I think the use of intalipid will help many people with otherwise unkown causes of infertility. Too bad many RE’s don’t belive that NKCs play any role in infertility and instead put those patients through repeated and failed IVF.
    I would like to know if Intralipid or IVIG can be used in a NATURAL cycle, (without the use of IVF or IUI or ovarian stimulation in a woman who has NO other issues other than High/Elevated NKC, and who has a normal 28 day cycke with proven natural ovulation.) If the only identified possible cause of infertility is the NKC then would it be reasonable to simply treat the NKC (removing that obstacle/cause) and let the couple attempt conception normaly or timed/planned for a few cycles?
    Thanks!

  2. Lisa Stack
    Lisa Stack says:

    Hi Elaina,
    Yes! We do use intralipids for natural cycles. You could set up a consult to speak with one of our physicians for more specific information.
    Best of luck!
    Lisa

  3. Colleen
    Colleen says:

    I live in SA and would like to try intralipids for a natural cycle. How do I use it during a natural cycle. Please let me know.
    Many thanx
    Colleen

    • Lisa Stack
      Lisa Stack says:

      Hi Colleen,
      You can use intralipids for a natural cycle. The timing would be unique to your cycle. However, they would typically be administered 4-7 days before your expected ovulation, and then again 4-5 weeks after a positive pregnancy test. If you would like to discuss this further, we can schedule a phone consultation.
      Please let me know if there is anything I can do to support you,
      Lisa

  4. marci
    marci says:

    Are NK cells the only autoimmune issue for which Intralipids are given? I have high TGaB thyroid antibodies(is that Hashimoto’s?)and figure I lost the last two babies at 11 wks due to those.
    Would you be likely/willing to give Intralipids in this case, and are NK cells usually common with autoimmune thyroiditis?

    • Lisa Stack
      Lisa Stack says:

      Hi Marci,
      I am so sorry for your losses. While we do give intralipids for multiple autoimmune issues, I would suggest a consultation (in-person or phone) to discuss your particular medical history. At our center, we always welcome new ideas, protocols, and treatments. So, even if we have not previously treated your particular conditions with intralipids, we will absolutely work to create a protocol that will suit your needs.
      Please give us a call! http://cnyfertility.com/about-us/contact-us/
      We hope to hear from you,
      Lisa

  5. Karen
    Karen says:

    I just saw this post. Since it was written in 2009, I was curious if you are now offering this in the Latham office.
    Thanks,
    Karen

  6. Karen
    Karen says:

    Hi Lisa,
    Thank you, you just made my day. I was diagnosed yesterday by a RI who is in NYC. Which is 4 hours away. Your latham office is 15 min. Away. I am going to contact Stacy ASAP….. This is so wonderful.
    -Karen

  7. Tania
    Tania says:

    Lisa,
    Hello, how are you today? I was reading the article and was wondering if this is something I ought to consider. I have lupus and am well aware that my body can turn on itself.
    Tania

    • Lisa Stack
      Lisa Stack says:

      Hi Tania,
      We have had clients try intralipids for Lupus and other related conditions. I would absolutely bring this up during your next appointment. It can’t hurt to try!
      Lisa

  8. Meredith
    Meredith says:

    Hi Lisa,
    I found out a while ago that my CD19 white blood count is at level 24 where the normal range is 5-17-is this a case where the intralipids would help with that? We will be moving to NY soon and am interested in your clinic>

    • Lisa Stack
      Lisa Stack says:

      Hi Meredith,
      Yes, intralipids would be used with a higher CD19. We have had great results with using intralipids in similar scenarios, and we would like to discuss your options further! Please feel free to schedule a consultation appointment, as soon as you feel ready. We also have phone consultations available, if you would like to get started before the move.
      Best of luck!
      Lisa

  9. Sherri
    Sherri says:

    Hi Lisa,
    I have Hashimoto’s with anti-TPO (along with slightly elevated NK cells, ANA, APA, etc.) and I see intralipids are given frequently to women with Hashi’s. But I thought that most Hashi’s women were sensitive to soy? Is the type of soy that’s in the intralipids something that is ok for Hashi’s patients? I would definitely rather have intralipids than IVIg, but I also don’t want to have a reaction. (which has already happened for me with iodine and iron)
    Thanks so much!
    🙂 Sherri

    • Lisa Stack
      Lisa Stack says:

      Hi Sherri,
      Many of our patients with Hashimoto’s use intralipids without any problems. I would suggest you email Meg (mmarnell@cnyfertility.com) with any specific questions regarding allergic reactions and intralipid therapy.
      Please let me know if there is anything else I can do!
      Lisa

  10. Shauna
    Shauna says:

    Hi Lisa,
    I went through a few unsuccessful rounds of IVF and was diagnosed in July (2010) with celiac disease (found to cause infertility). After going gluten-free, I tried another round (in Feb. 2011) and became pregnant. Sadly, the pregnancy did not get very far. Through consultation with the doctor, he has suggested we attempt intralipid treatments should I wish to go through it again. My question is, have you treated patients with celiac with intralipids and has it been successful?
    Always hopeful,
    Shauna

    • Lisa Stack
      Lisa Stack says:

      Hi Shauna,
      YES! We have treated many clients with intralipids, successfully. We have found great success with celiacs clients that remain strictly gluten-free, and intralipid therapy to support the immune system. I think it sounds like a great avenue to try. Please let me know if you have any further questions!
      Lisa

  11. Shauna
    Shauna says:

    Thank you so much. It is always helpful to read about the situations of others, and to hear about these success stories in an attempt to better guide us into these life altering decisions. If you have any further suggestions as to what might help this final attempt be more successful, I’d be happy to hear about them.
    Thanks again. All the best,
    Shauna

  12. Kelly
    Kelly says:

    Hi Lisa! I’m so glad I stumbled upon this article. I have auto-immune problems in my family – Mother/Brother: Celiac’s disease, Grandma: Lupus.. My Aunt has something as well, but I’m not sure of the name of it. My Grandma had secondary infertility (but eventually got pregnant after 10 years), and my Aunt and my cousin both had unexplained infertility for years before becoming pregnant (my cousin through IVF). My husband and I have been tested for everything – both completely healthy, great sperm counts. We’ve tried Femara and IUI, as well as acupuncture, Red Raspberry Leaf, “relaxing” etc. We’re on cycle #12 now and I’m at a loss. I had seen someone mention something about an overactive immune system and it’s relation to infertility, and when I googled it – up popped this page. Do you think with my family’s history and our fertility issues that getting the blood test for NK cells would be beneficial? Is it something most RE’s will run for you if you ask? We live in Buffalo, NY, so if I was tested and the test came back and showed there was an issue, we would be able to travel to Rochester for the treatment. We won’t be pursuing IVF, but I saw your comment to another woman that the treatment can be done even when doing a natural cycle (or IUI). I appreciate your input, thanks!! 🙂

  13. Kelly
    Kelly says:

    P.S. Sorry to add more, since my original question is so long, but I wanted to add that I am gluten intolerant, have eczema, a fainting condition called “neurally mediated syncope”, migraines, and hypoglycemia (low blood sugar). I’ve never been tested for Lupus (nor do I really seem to have symptoms), or as far as I know any specific auto-immune condition, but I thought my other ailments were worth mentioning. Thanks again!

    • Lisa Stack
      Lisa Stack says:

      Hi Kelly!
      I am so happy that you found this article. I think a consultation appointment would really be beneficial. There are a lot of treatments available for clients with autoimmune issues. We have had many clients end up with great results from intralipids, IVIG, and a few other protocols.
      I would suggest that you schedule a consultation appointment, and look into intralipids a little more! You never know if that may be just what you need!
      I also highly recommend meeting with one of our acupuncturists and/or a nutritionist to work through the gluten intolerance and eczema. Untreated celiacs and gluten intolerance can lead to infertility as well, so that is something to consider. I am also gluten free, and I would love to help you with navigating the gluten free aisle!
      Please let me know if there is anything else that I can do for you!
      Lisa

  14. Shauna
    Shauna says:

    I just wanted to pass along that after 4 unsuccessful IVF attempts I was diagnosed with celiac (the most likely culprit). I’ve been gluten-free for a year now, and doing the intralipid treatment has so far led to a successful IVF pregnancy. I am 15 weeks along and counting :). I don’t need you to respond, I just wanted to attest to the fact that intralipid treatments do seem to be a viable option for women with auto-immune disorders trying to get pregnant. Good luck!

  15. maroo
    maroo says:

    i’m living in Egypt and i want to try the intralipid in natural cycle and want to know the dose?? should i take the whole 500 ml??

    • Lisa Stack
      Lisa Stack says:

      Hi Maroo,
      Please contact our nursing staff, and they will be able to direct you to the most recent dosing research: 800.539.9870 (toll free)
      Best of luck!
      Lisa

  16. Ruben M
    Ruben M says:

    Hi I would just like to find out if this treatment would work for my wife Tanya? She had several operations to remove cysts on her womb (edometreosis). After some treatments, of which all failed, I was happy to read about your treatment!! Is there any hope?

  17. Nicole
    Nicole says:

    I have severe gutate psoriasis and my dermatologist has suggested using immunosupressive drugs such as Enbrel. I just completed 3 cycles of Clomid, the last at 150mg dose with no success in ovulating. Am I a candidate for intralipids since I have an immunity issue or would another fertility treatment be used first?

    • Lisa Stack
      Lisa Stack says:

      Hi Nicole,
      It sounds like there are a few factors to consider for your cycle. While intralipids have been a great support resource for many of our clients with immune issues, I’d like you to speak with one of our physicians to create the best plan for you. You can schedule a consult by contacting us here: http://cnyfertility.com/new-appointment-form/
      Please let me know if there is anything that I can do for you.
      Lisa
      Lstack@cnyfertility.com

  18. Mehgan
    Mehgan says:

    Hi all, so glad to see so many women finding the help they need for successful pregnancies! I was told that the standard tests my obgyn did ruling out an autoimmune disease left us with “unexplained” recurrent pregnancy loss. Interlipid therapy was mentioned, as sometimes therapies for diagnosed issues help undiagnosed ones. Are there new or better ways of diagnosing minor autoimmune issues (minor as in may not have prominent symptoms). If I could get a diagnosis for recurrent pregnancy loss I’d be open to paying for these newer treatments.

  19. Sherri
    Sherri says:

    Hi Lisa,
    I was wondering if your clinic ever treats patients remotely? (like if I forwarded all my tests results and medical records) I live in Los Angeles, and at the moment, it would not be financially possible for me to get to New York.
    I asked my RE here to Rx intralipids, but he said he couldn’t because he wasn’t familiar enough with them. My GP wouldn’t do it either. 🙁
    Thank you,
    Sherri

    • Lisa Stack
      Lisa Stack says:

      Hi Sherri,
      Yes, we do treat patients remotely. We will often monitor clients by utilizing your local physician, and have you travel to our center for your IVF or IUI. If you would like to pursue a cycle with intralipids, you would have to travel to our center for your IVF or IUI procedure. However, we could order your intralipids as needed once you are an official client. For more information about our cycles, please feel free to schedule a phone consultation: http://cnyfertility.com/new-appointment-form/
      Please let me know if there is anything else that I can do for you!
      Lisa

  20. amy
    amy says:

    Hi, I am a patient at the Syracuse office. I haved two IVFs, three eggs, two being frozen. I’m going through the third IVF and Intralipid Thereapy has been suggested. Just the idea of injecting a huge amount of “fat” into my body is an unnerving thought, because, well, I always thought too much fat is dangerous.

    • Lisa Stack
      Lisa Stack says:

      Hi Amy,
      Many clients believe that intralipids were exactly what they needed while trying to conceive. It is important to remember that our practitioners would not recommend a therapy if the risks outweighed the benefits. For example, it is not recommended to clients with a history of high cholesterol or liver issues. If you have any specific questions about the therapy, I encourage you to speak with a member of our nursing staff: 800-539-9870 #2
      Please let me know if there is anything else that I can help you with, and best of luck with your cycle!
      Lisa

  21. amy
    amy says:

    Thanks, Lisa. It has been confirmed that Intralip would not be ideal for me as I have a family history of high cholesterol, be it controlled by medications presently. I wish there was a way around this issue, but I wish everyone success with this fairly new development.

  22. Jenn
    Jenn says:

    How does Intralipids work with doing a donor cycle? Would it be recommended since you are using someone else’s eggs? Would it help your body so they don’t “reject” the eggs? Mind you, I have done IVF 5 times prior without ever getting pregnant (did Intralipids with some of the cycles).
    Thanks!

  23. Colleen
    Colleen says:

    Hi
    I am allergic to Soya and Gluten and Maize. Can I still do intralipids even though I am allergic to soya? Would this not lower my chance of pregnancy and let my immune system go hay wire? Please advise.
    Thanx
    Colleen

    • Lisa Stack
      Lisa Stack says:

      Hi Colleen,
      The Intralipid product is soy based, and so you are right to ask about your allergy. I recommend that you call our nurses for further information and guidance on your cycle. You can reach them here: 800.539.9870
      Please let us know if there is anything else that we can help you with!
      Lisa

  24. Valerie
    Valerie says:

    Hi Lisa,
    I am a patient at CNY with failed donor cycles. When I last consulted with Dr. Kiltz he suggested trying a cycle with intralipids. Is this something that you are tested for first, or is it just added to the protocol for your cycle?
    Thank you for your time,
    Valerie

    • Lisa Stack
      Lisa Stack says:

      Hi Valerie,
      As long as you are not allergic to soy products and you do not have a history of high cholesterol or liver disease, intralipids will typically be added to your protocol.
      This is a very easy therapy. It is an IV therapy session in our office. We have had great results from intralipid therapy, and many clients attribute their successful pregnancies to the introduction of intralipid therapy.
      Please feel free to ask our nursing staff any further questions that you may have, and best of luck!
      Lisa

    • Lisa Stack
      Lisa Stack says:

      Hi Angela,
      I’d like to refer you to our nursing staff for this question. They will be able to walk you through the Intralipid Therapy process, and direct you to any additional resources for the actual procedure. You can call our nurses here: 1-800-539-9870 option #2.
      Please let me know if there is anything else that I can do for you,
      Lisa

  25. Kehinde
    Kehinde says:

    Is my 1st iui with RE and purposely went to him for immune isseus but seems that i have to remind him of everything like my precription. I was told to come for iui 2/4/12 at 3.30pm and I ask him about the intralipid and he said I will do it the same day with iui.Is it not too late?, will it still work because I am double sure my problem is at implatation.

    • Lisa Stack
      Lisa Stack says:

      Hi Kehinde,
      I emailed you as well, so please let me know if you have any other questions. At our center, we typically administer intralipids during stimulation. If you would like to speak with one of our nurses about the timing of therapy, please feel free to contact us. They will be able to answer your questions in greater depth: 1-800-539-9870 option #2
      Please let me know if I can help you with anything else.
      Lisa
      Lstack@cnyfertility.com

  26. Xiomara
    Xiomara says:

    I have graves disease and have attemped 1 IVF cycle that failed. I was very surprised as I had always been furtile until dx with graves. I am 30 years old and having a hard time beleiveing that I cant get pregnant. Can this therapy work for me. PS I took radioactive iodine and tied my tubes in 04. 07 I has then reanistimosed and was found to have left tube patency but no pregnacy after trying since 07′. Am I a candiate for this procedure.

    • Lisa Stack
      Lisa Stack says:

      Hi Xiomara,
      Thanks for your inquiry! I would suggest that you contact our office to schedule a consultation. That way, we can look at your entire medical history to see if this would be a good fit for you. We also have many different medication and treatment protocols available, and we may be able to suggest a different protocol for you with more positive results. To schedule a consultation, please complete this form: http://cnyfertility.com/new-appointment-form/
      Please let me know if there is anything else that I can do for you.
      Lisa
      Lstack@cnyfertility.com

  27. Karin
    Karin says:

    Hello, I would like to ask wheter you could post me some links where I can find dosage recommendation on intralipid use, please. (I found several infos but they differed qiute a lot). I´m TTC after a pregnancy loss almost 7 month ago, without success and I was told ,tha the cause of this problem and the loss could be immunological. My NK cells are extremely high (almost 27 percent), I have positive ANA autoantibodies, autoimmune thyreoiditis and positive anti annexin V antibodies, as well. Unfortunately I live in Eastern Europe, I can´t find any doctor using IL in our country, but it´s available here, so my GYN could try to treat me with it.
    Thanks a lot.
    Karin

    • Lisa Stack
      Lisa Stack says:

      Hi Karin,
      I’m so very sorry for your pregnancy loss. I hope that you and your physician are able to find a protocol that works for you! In regards to intralipid dosing, I would suggest that you or your physician contact our nursing staff directly. They will be able to answer your questions the most accurately, and direct you to additional resources. You can reach our nursing staff by calling our office directly: 1-800-539-9870 (toll free) or 315-469-8700.
      Please let me know if there is anything else that I can help you with.
      Lisa

  28. Matako
    Matako says:

    I would like to inquire for my wife. We live in Hartford, CT and have gone through 4 IVF cycles with no success, my wife has endometriosis and received Lupron treatment 2 years ago. I wanted to inquire if we could come in just for the Intralipids therapy but continue on IVF in our fertility clinic in CT. If your clinic could prescribe and administer there if we bring all our infertility records. We would also be open to other treatments by your clinic but continue on IVF close to home. Our doctor is not familiar with Intralipids but does not object to trying a cycle with it.

    • Lisa Stack
      Lisa Stack says:

      Hi Matako,
      Thanks for your interest in intralipids! I’d like you to speak with one of our nurses, Meg. She will be able to help you determine the best way to proceed with your cycle. Please email her at: mmarnell@cnyfertility.com
      Also, please let me know if you have any further questions, or need any emotional support. Best of luck!
      Lisa

  29. Janet
    Janet says:

    Quick question:
    Do I need to test positive for an immune issue, before using intralipids for an IVF cycle? I once tested “borderline” for antiphospholipid antibodies and took heparin for an IVF cycle that resulted in a live birth. However, I would like to try intralipids for next time. Please let me know, thank you.

    • Lisa Stack
      Lisa Stack says:

      Hi Janet,
      No you do not need to test positive for immune issues to use intralipids for IVF. If you have any other questions about intralipids and IVF, I encourage you to contact our office to speak with a nurse: http://cnyfertility.com/about-us/contact-us/
      Please let me know if there is anything else that I can do for you.
      Lisa

  30. Marie
    Marie says:

    Do you know of a doctor in Florida that is familiar with Intralipid therapy. I have been through 4 IVF procedures, one didn’t take, one blighted ovum at 6 weeks and 2 that continued to grow but never showed a heartbeat and ended up with D&C’s at 9 weeks. I have been tested for everything with nothing standing out except my thyroid issues. I had Hashimoto’s and then Graves and have high AntiThyroid antibodies but my hormone levels are controlled. I even flew up to NY to see a reproductive immunologist who ran extensive tests and didn’t find anything definitive however, he did recommend trying another cycle using IVIG. I have since learned about Intralipid and think I would rather try that but I don’t know of anyone in Florida that does it. The 4 IVF cycles, trip to NY, and one unsuccessful cycle with a surrogate we are left financially unable to fly back up to NY or anywhere again. Any advice or help you could offer would be greatly appreciated. Thank you so much in advance for your time.

  31. lisa
    lisa says:

    Hi,
    I am under a FS in Adelaide. I have asked for intralipids to be used, after 25 x failed ivf/donor cycles.
    He has agreed, but he has no idea on when i should have them.
    I have so far had 1 done a week after my period, & a 2nd a week later, i go in for my ET in a weeks time. When should I have more done?

    • Editor
      Editor says:

      Hi Lisa,
      We welcome you to contact our nursing staff, for more information on the proper timing for intralipids. You are welcome to give us a call tomorrow! 1-800-539-9870
      Please let us know if there is anything else that we can do for you.

  32. Catherine
    Catherine says:

    I ordered intralipids for an upcoming IVF cycle…they were delivered to my house. How should I store them until they are ready to use? Or should I drop them off to the office until ready?

    • Editor
      Editor says:

      Hi Catherine,
      You can store your intralipids in a cool and dry location. A cabinet or shelf in your home should be fine. You will then keep them until your appointment. Please let us know if you have any questions about this, or your infusion. You can contact our nursing staff by using our toll-free number: 1.800.539.9870
      Best of luck!
      Lisa

  33. Michelle
    Michelle says:

    Lisa –
    I have a baseline appointment for tomorrow. I would like to speak to the nurse about this but how fast can this process begin? I am not sure if I am a candidate for this but I would like to inquire anyway.

    • Editor
      Editor says:

      Hi Michelle-
      Absolutely bring this up at your baseline appointment. It is very easy for us to add intralipids in and schedule your treatment, as long as you fall within the minimal guidelines we have. The challenging part right now is that there appears to be a shortage on intralipids within the country. However, once the clinical staff gives you the ‘OK’ to go ahead with intralipids, try contacting Apothecary by Design as I have heard they still have intralipids in stock.
      Best of luck!
      Lisa

  34. Michelle
    Michelle says:

    To olivebranch off my last email, I don’t have any know autoimmune issues but ever since my bartonella illness in my 20’s I have struggled with allergies, hives and other silly things were I feel my immune system was impacted. I just can’t help but think there may be something to all that. Guess it won’t hurt to inquire.

  35. Kim
    Kim says:

    I’ve had two transfers so far. The first time, I got “a lil’ pregnant”. I tested positive for Natural Cell Killers. The second time, I became pregnant. I received intralip infusion the day of transfer and two weeks later. I miscarried at 15 weeks. All of the tests came back normal. Should I have continued the infusion therapy?

  36. Kim
    Kim says:

    I currently live in Columbia, South Carolina, but in the process of moving to Huntsville, Alabama. We have 6 embryos left. We had sucess getting pregnant with the intralip therapy, but unfortunately loss the baby at 15 weeks. I did only two therapy sessions, before the transfer and afterwards. Could this have caused the miscarriage? All tests on the baby came back normal. What is the cost for Intralip Therapy at your facility?

    • Editor
      Editor says:

      Hi Kim,
      I am very sorry for your loss. We would be happy to work with you, to discuss the best intralipid protocol for your next pregnancy. To discuss your medical history and treatment plan, we request that you schedule a consultation with us. Phone consultations are available, and they are free: https://cnyfertility.com/new-appointment-form/
      You would acquire intralipids from a pharmacy, and we do offer the infusion service. Self pay infusion is $100
      We look forward to hearing from you
      Lisa

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