CNY Fertility Center innovative treatment called Intralipids to help women who have had recurrent miscarriage, multiple failed IVF cycles or multiple failed IUI cycles. Intralipids deactivate natural killer cells in a woman’s body which may prevent embryos from implanting and growing properly in the uterus.
New research has suggested that women who have experienced
recurrent miscarriages or multiple failed IUI or IVF cycles as a
result of natural killer cell activation may benefit from the use of
intralipids. Intralipids are synthetic and made from 1.2% egg
yolk phospholipids, 10% soybean oil, 2.25% glycerin and water.
It is administered through an IV 4-7 days before embryo transfer
Natural killer cells are regulated by the immune system. In
women who have autoimmune issues, the natural killer cells can
react abnormally to an implanting embryo, treating it as an
invading cell and signaling for the body to attack it. Studies
have found that intralipids can help to deactivate the natural
killer cells, allowing the embryo to implant on the uterine wall
and grow normally. Intralipids are re-administered 4-5 weeks
following a positive pregnancy test, to keep the natural killer
cells deactivated until the pregnancy can override the signals
being sent by the immune system.
Intralipids (approximately $100 per administration) are far less
expensive than Intravenous Immunoglobulin (IVIG) (approximately
$2000 per administration), and initial studies show
comparable efficacy for deactivation of natural killer cells and
pregnancy rates. Intralipids are well tolerated by patients with
few side effects and are created synthetically, unlike IVIG which
is a blood product. It takes about an hour and a half to two
hours for the intralipids to be administered through the IV.
For more information about intralipids call CNY Fertility Center or
ask your nurse if you are a candidate at your next appointment.