During a cycle, the female’s egg development will be monitored via Ultrasound and blood labs measuring estradiol (E2), progesterone and luteinizing hormone (LH). Some women may develop the eggs naturally, while others may need the assistance of Letrozole or Clomiphene Citrate (Clomid) to help in recruiting a follicle.
Letrozole helps by stimulating the release of follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) by the endocrine system. These two hormones help further guide the recruitment of other hormones that are essential for the ovarian cycle to function effectively.
Once a follicle has reached maturity (identified via Ultrasound), an injection of Human Chorionic Gonadotropin (HCG) – often by the brand name of Ovidrel/Novarel/Pregnyl or Leuprolide – by the brand name Lupron will be administered to induce ovulation. By triggering your ovulation via one of these medications, we can help ensure your ovulation takes place and know when it happens.
If your ovulation induction protocol calls for timed intercourse and not IUI or IVF, then you will be instructed to have intercourse on the day after your injection as well as two days later. To increase the amount of sperm ejaculated into the vaginal canal, we recommend the male partner abstain from any type of ejaculation for at least 3 days prior to trigger day.
An IUI is a fairly simple procedure that can be split into a few key components or steps.
Follicular & Egg Development
An IUI can be conducted during a natural cycle or with fertility medications depending on your preferences, history, and fertility diagnostic testing. Most often, you will be treated with medications that will stimulate egg growth and help time your ovulation with the insemination.
If given medications, you will likely be given Letrozole or Clomiphene Citrate (Clomid) which stimulate the release of folicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH further orchestrate follicular and egg development. Understand that any time medications are taken to stimulate the ovaries, there is an increased chance of multiples unless you are doing a single embryo transfer IVF. Although unlikely, it is possible that we advise you forgo a particular cycle’s insemination or convert your cycle to an IVF if we determine you are developing too many eggs to safely perform an IUI.
An IUI is performed as close to the day of ovulation as possible which is usually determined by using Ultrasound as well as blood tests to measure luteinizing hormone (LH). Ovulation may also be artificially induced if needed due to anovulation or to increase chances of successfully timing the insemination by using one of many trigger medications (HCG, Ovidrel, Lupron). Your IUI procedure will be scheduled the day after your trigger injection or positive LH test.
After collecting the male’s sperm, either by masturbation into a sterile cup or by sourcing through available donors, our team of dedicated andrologists prepares the sperm inside our andrology laboratory. To prepare the sperm, also known as washing the sperm, the andrology team first “spins,” the sample in a centrifuge. This results in a concentrated pellet of sperm at the bottom of the tube. The andrologist will then remove the seminal fluid “floating,” above the sperm. The seminal fluid contains proteins and hormones that can cause painful uterine contractions and allergic reactions in the woman thus interfering with potential fertilization. After removing the seminal fluid, the andrologist will add a special media into the vial. After some time, the most active sperm (the fast swimmers) will move up into the media. These sperm, now concentrated in the media, are ready for the insemination.
One of our registered nurses or nurse practitioners/physician assistants will perform the IUI. After washing and concentrating the sperm, it will be transferred to a catheter for the IUI procedure. During the procedure itself, the registered nurse, NP/PA will slide the catheter past the cervix and into the uterus. The sperm is then injected into the uterine cavity and the catheter is removed. This simple procedure only takes a few minutes and does not require any type of anesthesia. Usually, the procedure does not result in much discomfort, however, some mild cramping can be expected.
Following the Insemination
After the IUI procedure, you will be instructed to lay down for approximately 10 to 15 minutes. Afterward, you may resume your normal daily activity. Often, you will be instructed to take supplemental progesterone to help encourage implantation of the embryo by supporting the endometrial lining of the uterus.
Because IUI depends upon the sperm and eggs ability to come together and form embryos naturally, the success of IUI cycles is incredibly variable and depends largely on the age of the individuals, fertility history, and diagnosis, as well as the medication protocol used for the procedure. Generally, IUI’s offer a similar rate of pregnancy success as natural intercourse following a steady decrease with advancing maternal age. As such, IUI offers success rates anywhere between 3-25% per cycle.
An IUI costs $350.
- includes sperm wash and prep
The monitoring associated with the cycle costs either $725 or $850 for a natural/Clomid/Letrozole cycle and an injectable cycle respectively.
If your monitoring is done at CNY, the cost for your IUI would be either $$1075 or $1200.
This pricing does not include the cost of medication. The cost of medications varies widely based on your plan of treatment. If paying out of pocket, your medications will likely remain under $1200.
IUI cycles can be financed with our in-house payment plans for up to 6 months allowing you to make smaller more affordable monthly payments for as little as $220. We require at least the 1st month’s payment prior to insemination. Our in-house financing is interest-free, but we do add an account management fee of $250 for every 6 months. This equates to roughly $40 a month.
*prices listed above are for self-pay clients only.