Genesis-24, also known as Pre-Implantation Genetic Screening (PGS), is an IVF procedure designed to examine your embryos for chromosomal abnormalities. An embryo biopsy is taken either at day 3 or day 5 and Genesis-24 is used to examine all 24 chromosomes—the 22 non-sex chromosomes plus the two sex chromosomes (X & Y) in time for your embryo transfer. Chromosomal abnormalities can result in aneuploidy (embryos having the wrong number of chromosomes – i.e. extra copy of chromosome 21 also known as Downs Syndrome), translocations (chromosomes incorrectly rearranged), or other chromosome alterations that may be clinically significant. Genesis-24 aims at improving pregnancy and live birth rates by screening your embryos for chromosomal abnormalities and only implanting chromosomally normal embryos.
Genesis-24 screening can potentially benefit couples who present with the majority of IVF indications. Particularly advanced maternal age couples and families who have had recurrent pregnancy losses both naturally and through IVF.
A declining live birth rate is an increasing problem for families who choose to have children later in life and is strongly associated with late maternal age embryos showing greater levels of chromosomal abnormalities. Without Genesis-24, embryos are chosen based only on their visual quality and morphology, which cannot distinguish chromosomally normal embryos from abnormal embryos. In IVF cycles that incorporate Genesis-24, embryos are assessed by their chromosome content. Using Genesis-24 embryos with the normal number of chromosomes are selected and are more likely to result in a pregnancy that is carried to full term.
Genesis-24 screening utilizes the most sophisticated and scientifically validated technology for determining the chromosome compliment in a single cell. Comparative Genomic Hybridization (CGH) is a micro-array technology that compares the DNA in the embryo sample to a known normal control using thousands of genetic markers throughout the human genome. Our scientists obtain and interpret a computer generated map for each embryo sample. Genesis Genetics then provides a detailed genetic report to your IVF physician, indicating which embryos are chromosomally normal, in time for your embryo transfer.
This technology is the global standard. It is the only technology accepted by the European Society of Human Reproduction and Embryology (ESHRE).
At Genesis Genetics, we offer Pre-Implantation Genetic Screening (PGS) as an effective way to learn more about chromosomal abnormalities. It is estimated that 50% of human fertilizations carry the wrong number of chromosomes. As a result, a baby is typically not created from these abnormal numbers of chromosomes.
PGS testing can have multiple benefits for individuals looking to have a child. Some of the benefits of Genesis-24 PGS testing include:
Having PGS as a tool in your reproductive care can provide you and your physician with more information about your embryos and aid in minimizing the risk of transferring embryos with chromosomal abnormalities.
At Genesis Genetics, we understand that infertility can be an extremely sensitive and personal issue. This is why we are committed to unparalleled patient testing services throughout the entire Pre-Implantation Genetic Screening process. Pre-implantation Genetic Screening (PGS) is a comprehensive chromosome screening that examines embryos for chromosomal abnormalities. All 24 chromosomes (22 autosomes plus X and Y) are examined to evaluate any gains or losses of chromosomes, also known as aneuploidy.
Research has reported that as women age, the rates of developing abnormal chromosomes increases, while the chances of developing normal chromosomes decreases. It is theorized that over time, chromosomes in eggs become less likely to divide correctly leading to extra chromosomes or chromosomes that are absent.
At Genesis Genetics, we use the latest technology and procedures to screen embryos for chromosomal anomalies. A biopsy from your fertility center is sent to our labs for testing. Through this testing, we can scan thousands of sequences of DNA that are unique to each chromosome, accurately identifying abnormal gains or losses. As a result of Genesis-24 technology, fertility doctors are able to make more informed decisions as to which embryos should be implanted, giving you the best chances of a healthy pregnancy.
This technology allows us to work with patients of all ages and to screen for chromosomes that may have irregular features before implantation. With these advancements, our team at Genesis Genetics is able to identify chromosomal abnormalities to decrease the risks associated with aneuploid embryos, and help people achieve their dreams of parenthood.
Thank you to our friends at Genesis Genetics for sharing this content.
