Coenzyme Q10 (CoQ10) for Fertility

Coenzyme Q10 (Co Q10), also known as ubiquinone, is a naturally occurring biomolecule that can be taken as a dietary supplement to enhance both male and female fertility.  Co Q10 is present in every cell in the human body, and it helps generate energy in all cells.  As we age, our naturally occurring Co Q10 levels diminish.  This makes high-energy processes like sperm and egg development more difficult and less efficient.  

Supplementing Co Q10 increases levels in the body which can improve the quality of sperm and egg cells.  It can especially help those previously diagnosed with infertility, women who are struggling to get pregnant, and couples undergoing fertility treatment.

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Fast Facts About CoQ10 and Fertility 

  • Coenzyme Q10 levels in your body decrease as you age.  Taking Co Q10 supplements is a great way to increase your Co Q10 levels.
  • Women’s egg quality also decreases as they age.  The decrease in egg quality is caused by many factors, including the decline of chromosomally normal eggs.  
  • Like egg quality, men’s sperm quality decreases with age.  Co Q10 supplementation can help improve sperm parameters for older men and men with fertility issues.
  • Co Q10 is a potent antioxidant that can help protect cells from damage (including sperm and egg cells.)  
  • Sperm and eggs both take about 90 days to develop.  For best results, fertility specialists recommend taking Co Q10 and other fertility supplements for at least 90 days before trying to conceive naturally or with fertility treatment.   

How Co Q10 Works

Coezyme Q10 helps to improve fertility and the functioning of our cells in two main ways.  (1) CoQ10 is a vital part of the electron transport chain, which is responsible for generating energy in our cells.  When Co Q10 levels are higher, the electron transport chain works more quickly and efficiently to produce energy.  When more energy is produced, cells function at a higher level, positively impacting processes like sperm and egg development.   

(2) Co Q10 functions as a strong antioxidant.  Co Q10 works to protect our cells and decrease the damaging effects of free radicals on our reproductive system.  

Co Q10’s antioxidant properties and its contribution to cell energy production help to improve the quality of sperm and egg cells. 

CoQ10 for Egg Quality and Female Fertility

It is no secret that fertility declines as we age, and for women, that decline is much more rapid and drastic.  When we say women’s fertility declines as they age, what we are specifically referring to is the number of eggs they have available (ovarian reserve) and the quality of their eggs. 

As previously mentioned, Coenzyme Q10 levels also decrease as we age.  A 2015 study showed that suboptimal levels of Co Q10 can lead to oocyte deficits and age-associated causes of infertility .  The good news is that the same study produced results indicating that supplementing Co Q10 can help to reverse the age-related decline in oocyte quantity and quality.  In simpler terms, Co Q10 can help to combat age-related causes of infertility.  

Coenzyme Q10  doesn’t only help to combat age-related causes of infertility.  It has also been observed to improve fertility outcomes for younger women undergoing fertility treatment, especially those with poor ovarian response.  In a 2018 study, researchers measured the effects of Co Q10 pre-treatment on women with poor ovarian response who were scheduled to undergo IVF treatment.  Women pre-treated with Co-Q10 had less gonadotropin requirements, an increased number of retrieved oocytes, a higher fertilization rate, and produced more high-quality embryos compared to the non-treatment group.  The clinical pregnancy and live birth rates per embryo transfer were also higher for the Co Q10 treatment group.  Researchers concluded that Co Q10 improves ovarian response to stimulation and embryological parameters in young women with poor ovarian reserve .

CoQ10 for Male Fertility and Sperm Quality

The simplest way to assess male fertility is through a semen analysis.  A semen analysis measures several sperm parameters, including; sperm count, quality, density, motility, and more.  If you have undergone a semen analysis and received suboptimal results, you will want to pay special attention to this section.

In a recent study, researchers measured the effect of Coenzyme Q10 supplementation on the semen characteristics of men with idiopathic oligoasthenoteratozoospermia (OAT).  OAT is a condition that includes a low number of sperm, poor sperm movement, and abnormal sperm shape.  OAT is the most common cause of male subfertility.  Co Q10 treatment resulted in a significant improvement in sperm concentration from baseline, progressive motility, and total motility.  Researchers concluded that Co Q10 supplementation can help to improve several semen parameters, especially sperm concentration and motility .  

Co Q10 has also been documented to help men with unexplained infertility.  In one study, researchers measured the effects of Co Q10 treatment on several semen parameters and the seminal plasma antioxidant capacity in infertile men.  During the study, men treated with ubiquinol saw significant improvements in sperm density, sperm motility, and sperm morphology compared to the control group.  Total antioxidant capacity was also increased significantly .  

In another study, researchers produced similar positive results for the effect of Co Q10 supplementation on sperm parameters.  In this study, sperm parameters were measured at the start and end of Co Q10 treatment.  Total sperm count improved by 53%, and total sperm motility increased by 26% after supplementation .  

The concentration of CoQ10 in the blood has been shown to correlate with key semen parameters such as sperm concentration, motility, and morphology.  Researchers believe this is because Co Q10 supplementation improves total antioxidant capacity .

Coq10 Dosage for Fertility

Most people consume between 3mg and 6mg of Coenzyme Q10 daily through their diet alone, mainly by eating meat products.  For optimal results, fertility specialists recommend taking anywhere between 100mg and 300mg of Co Q10 daily.  Co Q10 is considered a well-tolerated and safe supplement, so there is less concern for taking too much, as there may be other nutrients.  

As with all nutrients or supplements, be sure to consult with your doctor, especially if you are taking medications, have health concerns, or are already pregnant.  

CoQ10 vs. Ubiquinol for Fertility

Co Q 10 is found in many different male and female fertility supplements.  On supplement ingredient lists, Co Q10 is commonly found by the names ubiquinone and ubiquinol.  Although the terms are sometimes used interchangeably, they are actually different forms of Co Q10.

In the body, Co Q10 exists either in its oxidized form, ubiquinone, or in its reduced form, ubiquinol. When oxidized Co Q10 (ubiquinone) is used by the body, it transforms and becomes ubiquinol.  This process is very easily done when we are young but becomes more difficult as we age.  The conversion process of ubiquinone to ubiquinol is complex and involves as many as five different enzymes .   

Recently, supplement brands have claimed that ubiquinol is a superior form of infertility supplement when compared to ubiquinone.  They claim ubiquinol has a higher absorbability and greater bio-availability. Some supplement brands will go as far as claiming that ubiquinol is eight times more absorbable than ubiquinone.  Conclusive research does not exist supporting the efficacy of one form of Co Q10 over the other. Both ubiquinone and ubiquinol are fat-soluble and not very absorbable on their own. We know that by taking ubiquinol, our body can skip the extra step of converting Co Q10 (ubiquinone) into ubiquinol. 

Choosing the Right CoQ10 Supplement for Fertility

When choosing fertility supplements, you want to look for products that contain the most absorbable and bioavailable forms of each nutrient.  The Co Q10 supplements we recommend contain a technologically advanced VESIsorb® delivery system which significantly increases the ubiquinol absorbability and bioavailability.  Ubiquinol in the VESIsorb® delivery system has been shown to increase peak blood levels of Ubiquinol by 696% and relative bioavailability by 485%.  By increasing the absorption and bioavailability of ubiquinol, these supplements produce faster and better results.  

The supplements we recommend at CNY Fertility are backed by peer-reviewed journals and clinical fertility care experience.  We have formulated what other Board Certified Reproductive Endocrinologists and we believe to be the best fertility supplements available, Molecular Fertility.

CoQ10 Supplement for Women

Ovarian Bloom is a specially formulated supplement designed to help females who are actively trying to conceive either naturally or with assisted reproductive technologies.  It is designed to provide women with the nutrients they require to improve the quality of their eggs.  Ovarian Bloom contains 200mg of ubiquinol and also contains the patented VESIsorb® delivery system.

CoQ10 Supplement for Men

Male Preconception + is designed to provide men with all the essential nutrients they need to maximize their reproductive and overall fitness.  All men can take Male Preconception +, but it is specifically designed for those trying to conceive naturally or with the use of assisted reproductive technologies.  It contains 100 mg of ubiquinol and also contains the patented VESIsorb® delivery system.  On top of its superior absorption, our products are combined with 100 mg of shilajit extract, which further increases energy production efficiency.

In Conclusion

We hope this article has not only educated you on the benefits of supplementing Co Q10 for fertility but that you can also use it as a guide for choosing the best fertility supplements.  As fertility supplements have increased in popularity, more and more products have become available.  Be sure to look for supplements with well-researched ingredients and nutrients that are highly bioavailable and absorbable.  

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