Unlike PGS, in which all of an embryo’s chromosomes are screened, PGD involves testing embryos for an already known chromosomal or genetic abnormality. While PGS is appropriate for almost any IVF patient, PGD is a good option for families who know they are at risk of passing on a specific inherited genetic disease. This includes families in which:
- Both partners are carriers of an autosomal recessive condition
- The female partner is a carrier of an X-linked condition
- One partner has an autosomal dominant condition
- One or both partners carry a chromosome rearrangement
Couples undergoing PGD often decide to add on PGS testing as well to gain even more information about their embryos’ health.
PGD can be performed for almost any condition in which the specific mutation or alteration is known, including cystic fibrosis, Fragile X syndrome, Huntington’s disease, and inherited cancer syndromes (e.g. BRCA).
PGD is a more involved process than PGS because the PGD test is created uniquely for each family. First, the family will speak with a genetic counselor to determine if PGD is appropriate for them. If they decide to move forward, the PGD laboratory will begin to build the family’s unique PGD test. Sometimes this involves getting DNA samples from other family members. Then, the couple will undergo IVF and a small sample of cells will be taken from the resulting embryos and sent to the laboratory for testing. Once the PGD procedure has been performed and embryos free of the genetic condition have been identified, an unaffected embryo is transferred to the uterus. Any additional unaffected embryos may be frozen for future use. While PGD helps reduce the chance of conceiving a child with a genetic disorder, it cannot completely eliminate this risk. Prenatal testing is recommended for any resulting pregnancies to confirm the health of the pregnancy. If you think PGS or PGD may be right for you, talk to your care team about getting started
CNY fertility charges $700 for up to 8 embryos and $75 per additional embryo for embryo biopsy. This fee does not include the actual testing by a third party lab.
Generally, PGD costs roughly $300-600 per embryo including our biopsy fee and third-party lab fees.