Fertility Supplements for Women:

The best fertility supplements for women can help fill common nutritional gaps that may affect egg quality, hormone balance, implantation, and early pregnancy development.

You can eat a balanced diet, exercise regularly, sleep reasonably well, and time intercourse around ovulation, and still not get pregnant as quickly as you hoped. Even well-planned diets often fall short on key nutrients like folate, vitamin D, iodine, choline, and omega-3 fatty acids.

That’s why many women start with a high-quality prenatal vitamin and add targeted supplements based on age, lab values, fertility history, or diagnoses like PCOS.

But with hundreds of products marketed as the best fertility supplements for women, it can be hard to know what’s worth it. Which ingredients matter most? When should you start? How do you avoid wasting money on unnecessary megadoses?

This guide breaks it down clearly. You’ll learn what fertility supplements are, when to take them, which nutrients have the strongest evidence, and how to choose the best option for your fertility goals.

Quick Guide: Best Fertility Supplements for Women

Most people don’t need 10 different bottles. A simple fertility supplement plan usually starts with a high-quality prenatal, then adds targeted supplements based on your goals, labs, and diagnoses.

Best Fertility Supplement for Women: How to Choose What Actually Matters

If your goal is to find the best fertility supplements for women, the “best” choice is the one that matches your actual needs and does not overload you with unnecessary megadoses.

Start with a prenatal you trust

A quality prenatal covers the basics (especially folate) and reduces the need to “stack” a bunch of separate products.

Choose add-ons based on a reason

A diagnosis (like PCOS), your age and egg reserve, lab values (like vitamin D), or a specific fertility history should guide what you add.

Look for label transparency and quality testing

Choose reputable brands that clearly list forms and dosages, and ideally use third-party testing.

Avoid kitchen-sink formulas if you’re sensitive

If supplements upset your stomach, simplify first, then add one product at a time.

Best Fertility Supplements for Women: Buyer Guide Checklist

This section is designed to satisfy “best fertility supplements for women” search intent without turning the article into hype. Use it to evaluate any brand.

Prenatal label checklist

Look for these nutrients on the label, then confirm the form and dosing align with your clinician’s guidance.

• Folate: confirm the form and amount (many people prioritize folate as the baseline preconception nutrient)
• Iodine: many clinicians recommend choosing a prenatal that includes iodine for preconception and pregnancy
• Choline: commonly missing from prenatals, often needs diet or separate support
• Vitamin D: deficiency is common, so this is one of the most frequent lab-guided add-ons
• Omega-3s (DHA and EPA): may be included in some prenatals, but many people add a separate fish oil

What to avoid when choosing the best fertility supplement for women

• Proprietary blends that do not disclose exact doses
• Megadoses without a clear reason or clinician guidance
• Duplicate ingredients across multiple products (common with vitamin D, B vitamins, iodine, and iron)
• Products that promise guaranteed pregnancy or claim to “reverse infertility”

Safety Notes Before Starting Fertility Supplements for Women

Even “natural” supplements can interact with medications or be inappropriate in certain conditions. If you’re under care (or on prescriptions), it’s worth a quick clinician check-in before adding a stack.

Common reasons to ask first:

• You have thyroid disease, kidney disease, or liver disease
• You’re on blood thinners, diabetes medications, or hormone medications
• You have PCOS and are already on metabolic support (to avoid doubling up)
• You’re already pregnant or may be pregnant (some supplements are not meant to continue unchanged)

What Are Fertility Supplements for Women?

You might be wondering what even are supplements for fertility.

In short, nutrients like vitamins, minerals, fatty acids, and amino acids are extracted from plant or animal food sources (or created synthetically in a lab) and turned into a pill, powder, or liquid form.

Consuming them in this form allows a person to augment their diet and increase their levels of a particular nutrient.

Usually, supplements are recommended for a specific purpose, such as improving egg quality, reducing inflammation, or increasing iron levels. Fertility supplements are formulated with one goal in mind: getting pregnant.

In general, fertility supplements are formulated to target one or more of the following:

• Improving egg quality
• Balancing hormones
• Improving embryo implantation odds
• Pregnancy and fetal support

Below, we’ll explain each of these ideas a bit more before sharing some specific nutrients you want to look for in a fertility supplement for women.

Supplements for Egg Quality

Egg quality is, in essence, a key measure of female fertility. There are a few ways to measure egg quality, including:

• From a genetic standpoint, the egg is chromosomally normal or abnormal, which determines its ability to develop normally and be fertilized
• IVF fertilization rates
• Number and quality of embryos in an egg freezing or IVF treatment
• AMH
• Implantation rates
• Pregnancy rates
• Live birth rates

The studies we examine later in this article will evaluate potential supplements for egg quality using these measurements.

Supplements to Balance Hormones

Your entire fertility is driven and governed by hormones. They are the chemicals that tell various body systems what to do and when to do it.

If your hormones are out of whack, chances are your monthly cycle and ability to conceive are also affected.

Your hormone balance is influenced by multiple factors, including stress and diet. Your body requires specific vitamins and minerals to synthesize hormones. An imbalance in, or complete lack of, certain nutritional precursors for hormones can disrupt hormonal balance.

Supplements to Improve Implantation

When achieved through intercourse, embryo implantation in the endometrial lining of the uterus happens around eight to nine days after ovulation and 5 to 6 days after fertilization (which takes place in the fallopian tubes).

After implantation occurs, a woman is considered pregnant. But not every embryo implants successfully (such is the case when trying naturally, IUI, and IVF).

Implantation failure can happen for a variety of reasons, including:

• Embryo quality, including chromosomal abnormalities of the embryo
• Uterine problems
• Systemic causes like inflammation, autoimmune disease, or endocrine and hormone imbalances and disruption

Female Fertility Supplements for Pregnancy Support and Fetal Development

Some nutrients help increase female fertility by supporting fetal development.

While fetal development may not seem like a “fertility supplement,” fetal defects can lead to pregnancy loss and lower the chances of a live birth, which is certainly the most important measure of fertility.

Folate and choline are important nutrients that fit into this category.

As you can see, each of these categories (egg quality, hormones, implantation, and pregnancy support) have quite a bit of overlap, and each is intimately connected to the main goal, a live birth.

Who Should Take Female Fertility Supplements?

Any woman planning to get pregnant should be taking supplements.

Of course, someone with no fertility issues should probably stick to the simpler side of things, with a high quality prenatal and fish oil.

Those with diagnosed female infertility or who are otherwise struggling to conceive should probably step up their game and look at supplements that specifically improve egg quality or other aspects of female fertility.

How Long Should a Woman Take Fertility Supplements?

What you’re taking is almost as important as when you start taking it. That’s because eggs start to develop approximately 90 days before they have the opportunity to be ovulated (or retrieved), and you’ll want those eggs to have grown the entire time in an optimal environment.

Furthermore, it’s important to build blood levels of certain nutrients critical for fetal neural development (like folate and choline) up to their desired state before pregnancy is achieved.

Achieving appropriate blood levels of these nutrients can take time.

Key Nutrients in Fertility Supplements for Women

Some of the most common and important vitamins and nutrients found in female fertility supplements are:

• Vitamin D
• CoQ10
• Inositol
• Omega 3s
• PQQ
• IgG
• Choline
• Folate
• Iodine
• Vitamin E
• Arginine

Below, we will go into specific studies and other details about each of these vitamins, minerals, and nutrients that are proven to boost egg quality and female fertility.

Vitamin D

Even with regular sun exposure and a healthy diet, most women don’t get enough vitamin D. Our skin uses sunlight to stimulate the production of vitamin D. However, nearly 40% of adults are deficient in this important fertility nutrient.

Some studies show this number to be even higher, partly because very few foods are a significant source, and you would need to eat a lot of them to consume the recommended 800 to 1,000 IU of vitamin D per day. This is particularly concerning for women trying to conceive since vitamin D plays an important role in fertility.

Additionally, low vitamin D levels have been associated with a long list of female fertility issues, endometriosis, PCOS, uterine fibroids, and lower pregnancy rates, all of which can make bringing home a baby quite a challenge even with the assistance of a fertility doctor.

A 2018 NIH study looked at vitamin D blood levels in approximately 1,200 women who had experienced a previous pregnancy loss before pregnancy and then again during their eighth week of pregnancy. Researchers found women with sufficient preconception vitamin D concentrations were 10% more likely to become pregnant and 15% more likely to have a live birth when compared to women with insufficient concentrations prior to pregnancy. Among women who became pregnant, each 10 nanogram per milliliter increase in preconception vitamin D was associated with a 12% lower risk of pregnancy loss. Vitamin D levels in the eighth week of pregnancy were not linked to pregnancy loss, suggesting the importance of preconception vitamin D in maintaining pregnancy.

An earlier 2009 study of women undergoing IVF concluded that each ng per mL increase in blood vitamin D levels increased the likelihood of achieving clinical pregnancy by 6%.

Additional studies have provided evidence that vitamin D levels play a critical role in predicting fertility success for women and men.

Given this, it’s critical to ensure you’re getting enough vitamin D each day, and fertility supplements for women are an easy way to make it happen.

CoQ10

Coenzyme Q10 (commonly called CoQ10) is part of the energy-producing mitochondrial chain that’s partially responsible for egg quality and fertility. It’s also an antioxidant that protects the mitochondria and helps defend against oxidative stress.

CoQ10 is naturally produced in the body, but it diminishes with age. CoQ10 has been shown to increase the number and quality of a woman’s eggs retrieved during an IVF cycle as well as lead to better fertilization rates, better embryo development, and a higher chance of pregnancy, all signs that demonstrate CoQ10’s value as a supplement for female fertility.

When used as a pre-treatment, CoQ10 has been shown to improve fertility outcomes in younger women with poor ovarian reserve who are undergoing fertility treatment, resulting in a need for fewer medications, a high number of eggs retrieved, better fertilization rate, and more high-quality embryos than women who did not pre-treat.

In one study involving 169 women, the study group was given 600 mg of CoQ10 for 3 months prior to undergoing IVF treatment while the control group was not. Women in the study group who took CoQ10 experienced higher fertilization rates (67% vs. 45%) and higher quality embryos.

Fewer women in the CoQ10 study group had their embryo transfers canceled because of poor embryo development than the women in the control group.

And the live birth rate was slightly higher in the CoQ10 group (28.95% vs. 15.54%). This study concluded that CoQ10 supplements could improve ovarian response in women who had previously had poor ovarian reserve.

Inositol

Inositol, in its most common form of myo-inositol, is a key fertility supplement for women that helps support normal and balanced glucose and hormone levels, and is considered by many to be the most important fertility supplement for women with PCOS.

Inositol is responsible for insulin signaling and glucose metabolism, which are common problem areas for women with PCOS. Indeed, many studies have shown that women with PCOS have high insulin levels coupled with low natural inositol levels, leading some fertility specialists to believe that insulin and glucose disturbances may be at the root of PCOS. Inositol also plays a role in many reproductive processes.

A 2021 study of poor ovarian responders undergoing IVF showed subjects who took 4 g myo-inositol plus 400 μg folic acid instead of the control group who took only 400 μg folic acid retrieved more eggs (oocytes) and transferred more embryos. The number of chemical and clinical pregnancies was higher.

Omega 3s

Omega-3 fatty acids, like those found in wild-caught sardines, anchovies, and mackerel, are another important fertility supplement for women that help support hormone balance and synthesis and improve female fertility because they are used in hormone production and function. Omega-3s can also help regulate the menstrual cycles of women with PCOS.

A 2018 study of women receiving fertility treatment showed that higher levels of omega-3 fatty acids were associated with a higher probability of clinical pregnancy and live birth. The probability of clinical pregnancy and live birth increased by 8% (4%, 11%) and 8% (95% CI: 1%, 16%), respectively, for every 1% increase in omega-3 levels.

Additionally, there’s evidence to suggest that omega-3 fatty acids may help delay ovarian aging and improving oocyte quality in older women. Its anti-inflammatory properties may also prevent endometriosis, as women with high levels of omega-3s were less likely to have endometriosis than women with low EPA levels.

PQQ

Pyrroloquinoline quinone (PQQ) is a powerful antioxidant that stimulates the growth of new mitochondria. Mitochondria generate most of a cell’s energy supply and turn nutrients into useable energy at the cellular level. Mitochondrial dysfunction is a symptom of age and disease. It directly affects egg quality.

Most research about PQQ and its positive effect on female fertility has been entirely on animals. However, PQQ supplementation was shown to improve the reproductive performance and growth of mice and rats.

PQQ is usually recommended to be taken in conjunction with CoQ10 to optimize mitochondrial function and repair.

IgG

Immunoglobulin G, or IgG, is part of a family of immune-fighting molecules found everywhere in the body. IgG works primarily by binding with antigens in the gut to prevent them from entering the body and causing inflammation or damage and helps to provide immune protection from various toxins, viruses, and bacteria.

Keeping inflammation in check and a healthy digestive tract are factors that play a role in promoting fertility. Because IgG reduces inflammation, it can be effective in improving a woman’s chances of conceiving.

Folate

Folate is well-known and one of the best female fertility supplements that helps support egg and ovulatory structure and function and helps reduce the risk of neural tube defects.

All women who plan to become pregnant are advised to increase their folate intake at least three months prior to conceiving.

Recent research also supports its use as a supplement for improving fertility in women trying to conceive naturally and those using fertility treatment.

Studies show that folate can improve oocyte counts and embryo quality in couples undergoing fertility treatment, and found that women with higher folate levels in their blood were 162% more likely to have a live birth than women with lower folate levels.

Choline

Less acclaimed than folate, but equally important for supporting fetal development is choline. New research shows that choline plays a critical role during the prenatal period, helping with multiple functions, including tissue expansion, brain development, and neurotransmission.

The human body naturally produces some choline, but food is our major source. It helps support cell growth, metabolism, liver, and muscle function.

Because of choline’s importance in fetal development, it’s surprising that many prenatal vitamins don’t include it as a standard nutrient. It’s important to check the label to ensure you’re getting enough choline if you’re planning to get pregnant.

Iodine

Iodine is another female fertility supplement that’s critical to normal fetal brain development.

Your thyroid gland requires iodine to produce thyroid hormones, which regulate the body’s metabolism, help control cell growth, and repair damaged cells. In utero, babies require thyroid hormones from their mothers for brain development. Low maternal levels of iodine during pregnancy can impair fetal neurodevelopment.

Iodine deficiency is widespread, particularly among pregnant women. A study of close to 500 women demonstrated that women with iodine levels in the moderate to severe deficiency range took significantly longer to become pregnant.

For a practical checklist: many clinicians recommend choosing a prenatal that includes iodine; NIH’s ODS iodine fact sheet includes RDAs and pregnancy guidance.

Vitamin E

Vitamin E is a fat-soluble vitamin essential to many physiological functions and processes. In women, vitamin E plays an important role in maintaining proper reproductive system function.

Vitamin E has been shown to improve endometrial thickness, and has proven beneficial to infertile women in several clinical studies.

Arginine

L-arginine is an amino acid that helps the body build protein and produce nitric oxide (NO), which plays an important role in the cardiovascular system because it allows blood vessels to dilate or open.

For women, arginine can improve blood circulation in the uterus and help improve the thickness of the endometrial lining, which can make implantation more likely. Another small study also explored L-arginine as an adjuvant in IVF poor responders.

The Best Fertility Supplements for Women

Many of the nutrients listed above like choline, folate, iodine, and vitamin D are found in most high-quality prenatal vitamins. That means you can greatly reduce the number of different supplements you need to buy (and take each day) if you start with a well-formulated prenatal and then add on others like CoQ10, fish oil, PQQ, and inositol as needed. In fact, some of the best fertility supplements for women even combine these.

At CNY Fertility we generally recommend a combination of Molecular Fertility products. These supplements were designed by leading experts in fertility and backed by science in peer-reviewed journals and clinical fertility care experience.

Peak Prenatal

Peak Prenatal is a well-formulated fertility supplement for women that should be ideally taken starting 90 days before planning to get pregnant. It contains many of the nutrients listed above.

In fact, it features 41 nutritional ingredients, including 14 patented and trademarked nutrients that have clinically demonstrated absorption, bioavailability, comfort, and or superior efficacy compared to their generic vitamin and mineral counterparts. Peak Prenatal helps support egg and preconception health, pregnancy and healthy fetal development, and supports mom and baby into and through the 4th trimester.

VivoMega Fish Oil

VivoMega Fish Oil is a great source of omega-3 fatty acids that help support egg quality, hormone function, and overall female reproductive health. Omega-3s support a host of other systems for your general health and wellbeing, including brain, heart, and immune health.

VivoMega Fish Oil is a top-quality blend of natural fish oil sourced from sustainable, wild-caught sardines, anchovies, and mackerel that are refined and concentrated in Norway with an ultra-high concentration of omega-3 fatty acids (70%) and the highest levels of purity on the market.

Ovarian Bloom

Ovarian Bloom is an effective supplement for egg quality and is uniquely formulated to support egg, ovarian, ovulatory, and uterine health with nutrients to boost female fertility like vitamin E, CoQ10, vitamin D, myo-inositol, and PQQ. It also includes antioxidants to help protect ovarian, fallopian, uterine, egg, and other cells from free radicals that may cause damage.

Fertile Guard

Fertile Guard Immunoglobulin (IgG) is derived from milk and binds and neutralizes antigens like viruses, bacteria, and other toxins in the digestive system to protect the body from damage. It helps support the immune system by reducing the level of inflammation-causing antigens from entering or interacting with the body. This can boost fertility by controlling inflammation.

Ubiquinol

Ubiquinol featuring VESIsorb is one of the most advanced ubiquinol products on the market and helps support healthy egg quality. Ubiquinol is a form of CoQ10 and supports egg and embryo quality, improving pregnancy rates. It also supports mitochondrial function and the generation of natural cellular energy.

Other Helpful Tips

Exercise

There is such a thing as too much of a good thing, at least that’s the case with exercise. Intense, repetitive motion activities can increase inflammation in the body and contribute to injury. Walking, yoga, Tai Chi, a casual bike ride, moderate weight lifting, and other moderate-intensity movements are perfect for keeping inflammation at bay. Avoid sprinting and heavy weights.

Diet

What and when you’re eating play a huge role in conception. For best results, a fertility diet that’s high in fats, moderate in protein, and low in carbohydrates can increase sperm quality, egg quality, your chances of achieving pregnancy, reduce the risk of pregnancy complications, and optimize your overall preconception wellness.

Soak Up the Sun

Natural sunlight is a good source of vitamin D. Experts recommend about 20 to 30 minutes of sun exposure (without sunscreen) three times a week if you have fair skin, but timing varies based on weather, skin exposure, skin color, time of year, and many other variables. The sun is good; getting sunburned isn’t, so soak it up responsibly. 

Stop Smoking

If you smoke and wish to conceive, quit now. Smoking and fertility don’t mix. For women, the percentage of women experiencing conception delay for over 12 months was 54% higher for smokers compared to non-smokers.

Limit Alcohol

Regular consumption of alcohol can impair your fertility. A study published in Obstetrics and Gynecology found that women beginning an IVF treatment who drank four or more drinks per week were 16% less likely to have a live birth than those who drank less than that or not at all.

FAQ: Fertility Supplements for Women

What is the best fertility supplement for women to start with?

For most people, the best “starter” fertility supplement for women is a high-quality prenatal vitamin taken consistently, ideally beginning at least 90 days before trying to conceive.

What are the best fertility supplements for women beyond a prenatal?

The most common add-ons depend on your goals and history, but many women consider options like omega-3s, CoQ10 (especially for egg quality support), myo-inositol (especially in PCOS), and vitamin D (especially if low on labs). Your clinician can help tailor this.

When should I start fertility supplements for women?

A practical timing rule is to start at least 90 days before you want to conceive, because that’s the approximate window of egg development before ovulation.

Do fertility supplements for women actually work?

Some supplements have stronger evidence in specific situations (for example, certain supplements used in PCOS or in IVF contexts), while others are more about building a solid nutritional foundation before pregnancy. The most reliable approach is starting with a quality prenatal and adding targeted supplements based on your diagnosis, labs, and fertility history.

Can a fertility supplement for women replace a prenatal?

Usually, no. A fertility supplement for women may focus on egg quality or hormone support, but a prenatal is designed to cover core preconception and early pregnancy nutrients (especially folate), which is why many plans use a prenatal as the “base.”

Are fertility supplements for women regulated like medications?

Dietary supplements are not regulated the same way as prescription medications. This is one reason label transparency and third-party testing matter when choosing the best fertility supplements for women.

The Bottom Line About Fertility Supplements for Women and Improving Egg Quality

Without a degree in nutrition or food science, it’s really difficult to know exactly what nutrients you’re getting enough of and which you’re lacking. Fertility supplements for women are an easy and convenient way to ensure your blood levels of all of the critical fertility-enhancing vitamins and nutrients are at the recommended levels prior to conceiving.

With statistics that show a large portion of the population is lacking in vitamin D, choline, iodine, and several other nutrients, it becomes clear that today’s diet alone isn’t enough to get the job done.

Choose a reputable fertility supplement brand, and start your supplement regimen sooner rather than later, whether you’re trying to conceive naturally or with fertility treatment, since it takes upwards of 90 days for eggs to develop.